Open until filled

To fulfil our mission, we shall be recruiting THREE PhD candidates join a small and highly dynamic team of researchers (biophysicists, biochemists, computational biologists) to work on the following projects

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Project 1 – Long range cell-cell communication under surface adhesion, fluid flow and 3D microstructure

 In tissue biology, communities of cells interact with the local environment to form whole tissues that then join to become entire organs. Adherent and differentiated cells exist in a tissue matrix that supports their survival and proliferation are constantly being exposed to different environmental cues. ​Here, we aim to investigate long range cell-cell communication that leads to directional cell migration and formation of tissue units. Our goal is to study how dynamics extracellular conditions, adhesion, fluid flow and microstructure control and regular direct cell-cell communications.

 

Project 2- Creating micro-Avatar of Tissue for disease modelling

Many lessons in interconnecting tissue can be learnt from epithelial biology particularly the role of cadherin driven cell junctions. We observed that between different Micro-Avatar of Tissue (MAT) forms cellular networks. We aim to develop bioreactor technologies to promote de novo-grown MATs i.e. reciprocal feedback between MAT stroma, fluid and their environment.

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Project 3 – Spatial Adaptive Imaging for Clinics

Single cell technologies have emerged as a multi-billion-dollar industry that has grown by approximately $300 million in the last 12 months to $2.9 billion. A major challenge of all single cell technologies is the requirement to perform tissue dissociation to isolate large populations of single cells from whole tissue. This project generates a new class of Spatial Adaptive Imaging (SAI) technologies that surpass single cell and imaging microscopy techniques to image up to millions of single cells in one image, with the highest resolution.

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Unlimited access to cutting edge biophysical tools:  SAIL combines 4D imaging and lithography to support and maximise convergence of organoids and spheroids technologies for 3D Cell based assay development

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Our expectations: Applicants are required to hold a 1st Class Honours or Master’s degree in the biophysics and/or biological sciences or other basic science disciplines in physics, chemistry and biology. A good command of the English language is necessary.  We also welcome cell biologists with previous experience in advanced fluorescence microscopy as well as computational biologists with experience advanced image data analysis. At the ANU, we strongly support equal opportunity and diversity. We welcome all applicants regardless of sex, nationality, ethnic or social background, religion or worldview, disability, age, sexual orientation or gender identity. We are committed to creating family-friendly working conditions. We actively encourage applications by women.

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Please send an electronic application including your CV, a short motivation letter and two references to Dr W M Steve Lee